Votrient 400mg (Pazopanib)

What is Votrient 400 mg?

Votrient is an orally anti-cancer drug prescribed for cure of renal cancer (renal cell carcinoma) and advanced soft tissue cancer called sarcoma. It is a combination of Pazopanib which is a tyrosine-kinase inhibitor which works by blocking specific enzymes that are responsible for the growth of cancer cells, eventually aiding in stopping or slowing the growth of tumors.

Kidney cancer is a condition that occurs in the event that abnormal cells start to expand in the kidney, but there are many types of cancerous growths. The Renal Cell carcinoma is the most prevalent type among adulthood. It is typically accompanied by symptoms like fatigue, abrupt weight reduction as well as blood in the urine, a loss of appetite and constant back pain. the back.

Votrient 400 mg can also be beneficial in the treatment of soft tissue Sarcoma which is a type of cancer which develops within the body’s soft tissues which include fat, muscles and nerves, blood vessels along with tendons and joints’ lines. The disease can occur throughout the body but typically it affects the legs, arms and the abdominal region.

Uses of Votrient 400 mg

Treatment of Kidney Cancer (Renal Cell Carcinoma)

• In adults, it is used to control advanced renal cell carcinomas by slowing tumor growth and limiting the spread of cancer.

Management of Advanced Soft Tissue Sarcoma

• For patients who been treated for cancer in the past however did not show any improvement.
• It helps to stop cancer cell growth in soft tissues like the muscles as well as nerves, fat blood vessels and the tendons.

Targets Tumour Growth Pathways

• It contains Pazopanib is an inhibitor of tyrosine kinase that block specific proteins involved in the growth of cancer cells and their survival.

Used When Other Therapies Fail or Are Not Suitable

• It is often recommended for cases when conventional treatments or chemotherapy are inadequate or ineffective.

Mechanism of Action

The main ingredient in Votrient 400 mg dose, Pazopanib is beginning to show that it’s effects through reducing flow of blood to cancerous tumors, to slow down the growth of cancerous tumors.

Dosage and Administration

It is suggested to take the dose at least once per day with no eating (or it is possible to consume the dosage an hour prior to a meal, or just a few hours prior to a meal)

for Urothelial Cancer:

• The first dose is reduced to 400 mg once orally, every day
• 2nd dose reduction: 200 mg per day, taken orally.

For soft tissue sarcoma:

• The first dose is reduced to 600 mg once orally every day
• The second dose is reduced to 400 mg taken orally, once per day

Note: Permanently discontinue therapy when patients are not able to handle another dose reduction.

Indications

The Votrient is one of the types of kinase inhibitor utilized to treat advanced renal cell carcinoma as well as advanced soft tissue sarcomas, which is administered prior to chemotherapy. Prior to determining Votrient 400 mg price, it is important to know the Votrient 400 mg cost it is crucial to fully understand the medicine. However, there are limitations when it comes to using this treatment to treat adipocytic tissue sarcoma or stomach cancers, which aren’t treated.

Side effects

• Diarrhea
• Vomiting
• Nausea
• Headache
• Loss of Appetite
• Weight Loss
• Numbness
• Tingling Sensation
• Redness in Hands/feet
• Feeling of Weakness
• Temporary Hair Loss
• Change in Skin or Hair
• Swelling Feet/Ankles
• Unusual Weight Gain
• Slow Heartbeat
• Sore Throat
• Chills
• Cough
• Fever

Contraindications

• Fexinidazole
• Alemtuzumab
• Hydroxychloroquine
• Itraconazole
• Lemborexant
• Mifepristone
• Nizatidine
• Pacritinib
• Ranitidine
• Thioridazine
• Ziprasidone
• Amprenavir

Precautions and Warnings

• Tell your physician about any reactions in response to sunitinib, sorafenib, or the drug pazopanib.
• When you’re in treatment, ensure that you have regular blood tests and blood pressure measured. In the event of abnormal test results or blood pressure you may have your dose modified.
• You can try taking this medicine in a stomach empty.
• It is not recommended to break, chew or break the tablet. Take the tablet whole.
• Avoid drinking grapefruit juice until when the treatment has been completed.
• If you drink alcohol take it in smaller amounts. Ingestion of alcohol in large quantities may affect the efficiency of Pazopanib.
• It is very likely Pazopanib could begin to cause damage to the Sperm count, and possibly affect the baby’s health if taken in pregnancy.
• The tablet should be kept secure in a sealed container from reach of kids when it is at room temperature.
• The CYP3A4 inhibitors should be avoided because they have powerful inhibitors. It is likely that your doctor will reduce the dosage when administered using strong CYP3A4 inhibitors.

Conclusion

Votrient is a powerful protein kinase inhibitor that is used to treat kidney cancer as well as soft tissue Sarcoma. There are some side consequences such as high blood pressure diarrhoea and diarrhoea as well as reduced blood vessels, which is why constant monitoring is crucial. Notify symptoms of chest breathing problems, fever or symptoms resembling flu to your physician. Tell your physician about any kidney, liver or heart issues. It is also possible to check the price on the internet prior to buying.

FAQs:

What to Do in Case of a Missed Dose?

If you did not take the Votrient 400 mg dose, you should try to take it as soon as you can, that means within 12 hours from the dose that you skipped. If you are twelve hours after when you first missed the dose, do not take the dose you missed and re-evaluate your dosage schedule.

What is the best way to take Votrient 400 mg?

Prior to taking Votrient 400 mg you must review the prescribed. The Votrient 400 mg, without eating food once per every day. The best way to use this medication on a empty stomach. It is recommended to take it for at least one hour prior to or following several hours after an eating. The medicine must be swallowed by swallowing the entire tablet. Do not take it in a chewing motion, crush, or smash the tablet. If you do this the tablet could release the drugs needed or cause more adverse consequences.

What is Votrient 400 mg function?

Its tablet Votrient 400 mg contains anticancer medication. It begins to show its effectiveness in the beginning by binding to and blocking the enzyme receptors i.e. Tyrosine Kinase. It’s responsible for the proliferative growth in cancerous tumors. It begins by limiting new blood vessel development in the tumor.